The detectors represent the core hardware of the WFC3 instrument. WFC3 will utilize two 2K x 4K pixel CCD detectors from E2V Technologies. By coating the detectors with special anti-reflective coatings, they may be made extremely sensitive in spectral areas previously unavailable. Advances in UVIS technology will allow extremely high quantum efficiencies, better than 50%, or one-half electron/photon per pixel. Together with the large format of the UVIS array, this will allow high resolution imaging at a broader spectral range than ever before. With these highly efficient detectors, the entire instrumental efficiency can be raised significantly above current capabilities.